At 10:48 C-Shift responded to a reported structure fire at 212 South Hillsborough Avenue, in the historic district. Ladder 271 arrived on scene and found a two story structure with flames visible from the roof and rear of the structure. An aggressive fire attack was initiated and the building was searched for occupants. The fire was under control in approximately 25 minutes. The cause of the fire is currently under investigation by the Orange County Fire Marshal's Office. There were no reports of injuries and Orange Rural Fire Department cleared the call at 13:33.